EXCRETION BALANCE AND URINARY METABOLISM OF INDOBUFEN IN RATS AND MICE

The excretion balance and the urinary metabolism of indobufen (+/-2-[p -(1-oxo-2-isoindolinyl)-phenyl] butyric acid), a platelet aggregation inhibitor, has been studied in rats and mice after oral administration . The urinary metabolic profile of indobufen exhibited a marked specie s difference. The major metabolic pathway in the mouse was acyl glucur onidation followed by renal excretion, whereas in rats, 5-hydroxylatio n and subsequent sulphation at the introduced hydroxyl group predomina ted. Comparison of these results with previous data obtained in humans indicates that the mouse, and not the rat, is the rodent species of c hoice to be considered in the study of this compound.