AN ANTAGONIST OF GLUTAMATE METABOTROPIC RECEPTORS, (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE, PREVENTS THE LTP-RELATED INCREASE IN POSTSYNAPTIC AMPA SENSITIVITY IN HIPPOCAMPAL SLICES

Authors
SERGUEEVA OA FEDOROV NB REYMANN KG
Citation
Oa. Sergueeva et al., AN ANTAGONIST OF GLUTAMATE METABOTROPIC RECEPTORS, (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE, PREVENTS THE LTP-RELATED INCREASE IN POSTSYNAPTIC AMPA SENSITIVITY IN HIPPOCAMPAL SLICES, Neuropharmacology, 32(9), 1993, pp. 933-935
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
32
Issue
9
Year of publication
1993
Pages
933 - 935
Database
ISI
SICI code
0028-3908(1993)32:9<933:AAOGMR>2.0.ZU;2-7
Abstract
(RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), a compound which sele ctively antagonizes metabotrtopic glutamate receptors (mGlu-R), precen ts the LTP of field excitatory postsynaptic potentials (fEPSP) as well as the tetanus-induced increase in AMPA-evoked responses (fPRs) in th e CA1 region of hippocampal slices. This effects of MCPG provide evide nce for the involvement of mGlu-Rs in mechanisms underlying the postsy naptic maintenance of LTP, which appears to be mediated, at least part ially, by an increase in sensitivity and/or number of postsynaptic AMP A receptors.