IN-VITRO EFFECTS OF RT-PA ON PLATELET-FUNCTION AND CLOT STRENGTH

Bleeding is a complex complication of thrombolytic therapy with recomb inant tissue-type plasminogen activator (rt-PA). Among the hemostatic causes, reduction of plasma fibrinogen concentration, presence of FDP, platelet dysfunction and weak clots are some attributed reasons for t his event (1,2). As bleeding is also reported after local low-dose the rapy (3), this study was designed to evaluate the in vitro effects of rt-PA at low and high final concentrations (1 and 20 mu g/ml) on the a bove mentioned parameters.