Objective-To study associations between characteristics of families du
ring the first pregnancy and after childbirth and the development of i
nfantile colic. Design-Randomised, stratified cluster sampling. Follow
up from the first visit to a maternity health care clinic during preg
nancy to three months after birth with confidential semistructured que
stionnaires. Setting-Maternity health care clinics in primary health c
are centres in Finland. Subjects-1443 nulliparous women and 1407 partn
ers. Altogether 1333 women and 1279 men returned the questionnaires. W
hen the infants were 3 months old 1208 women and 1115 men returned que
stionnaires. Main outcome measures-Marital relationship; personal and
social behaviour of parents during the pregnancy and their coping with
the pregnancy; mothers' physical health and events, symptoms, and exp
eriences in relation to pregnancy; self confidence and experiences of
mothers and fathers in relation to childbirth; and parents' sociodemog
raphic and educational variables. Measure of colic when the infant was
3 months old. Results-Experience of stress and physical symptoms duri
ng the pregnancy, dissatisfaction with the sexual relationship, and ne
gative,experiences during childbirth were associated with the developm
ent of colic in the baby. None of the sociodemographic factors was ass
ociated with colic. Conclusions-Early preventive health work during pr
egnancy should attempt to improve parents' tolerance of symptoms of st
ress and ability to cope and increase their confidence in parenting ab
ilities.