The occurrence and fine structure of Merkel cells with melanosomes in
the labial epithelium of the dog and cat were studied by electron micr
oscopy. These melanosomes were polarized in the Merkel cell cytoplasm
opposite to the major aggregation ot dense-cored granules and the clos
ely abutting nerve terminal. None of melanosomes was found in the Golg
i complex region where a few immature dense-cored granules were observ
ed. This may suggest that the melanosomes are not produced in the Merk
el cell, but are taken from the melanocytes like in keratinocytes. The
possible phagocytotic ability of Merkel cells is discussed.