IN-VIVO EFFECT OF GANGLIOSIDES ON NONOBESE DIABETIC MICE

Non-obese diabetic mice were administered 150 mg/kg body weight of Cro nassial daily from the 5th to the 11th week of life. Animals were kill ed either at the end of the treatment with Cronassial (week 11) or at week 21. The results obtained demonstrated that the appearance of the insulitis in control and treated animals at 11 and 21 weeks did not sh ow a significant difference. The only effect of ganglioside treatment was to slow the rate of rise in glycaemia and the progression of the i slet cyto-architectural derangement. In our opinion, this is not suffi cient to prove the effectiveness of this drug in reducing the final di abetes incidence.