CLINICAL RISK-FACTORS FOR MALNUTRITION IN HIV-1-INFECTED PATIENTS

Objective: To estimate the influence of fever, diarrhoea, stage of HIV disease, opportunistic infection and anorexia on malnutrition in HIV- infected patients we analysed data of patients undergoing a nutritiona l counselling programme from November 1989 to April 1992. Patients and methods: Our study group comprised 104 HIV-infected patients (98 homo sexual men, 15 asymptomatics, 30 AIDS-related complex patients, 59 AID S patients). Nutritional status was measured by previous weight loss, bioelectrical impedance analysis and prospective intake protocol. Resu lts: Patients had lost 10 +/- 8.7% of body weight. Compared with contr ols, body mass index was lower (P < 0.001), and extracellular/body cel l mass ratio (ECM/BCM) was higher (P < 0.001). BCM was reduced proport ionately to weight loss, percentage of body fat was lower compared wit h controls (P < 0.001), even in patients with stable weight. Clinical risk factors for malnutrition were identified as fever in 31, diarrhoe a in 26, acute infections in 42 and anorexia in 73 out of 104 patients . One single risk factor was predominant in 63 patients: fever in five , diarrhoea in 14, acute infections in 17 and anorexia in 27 patients. Weight loss was not linearly correlated to CD4 count or to time since AIDS diagnosis. Food intake was highly variable (39-165% of calculate d needs) without correlation to weight loss. Conclusions: Loss of body fat was found even in the earlier stages of HIV infection and was mor e severe than loss of BCM. Important risk factors for malnutrition are anorexia (most frequent), diarrhoea and fever (most severe). Most pat ients have combined risk factors. Treatment strategies and pathophysio logic studies should consider the heterogeneity of HIV-associated maln utrition.