FLUORESCENT IN-SITU HYBRIDIZATION (FISH) - A NEW APPLICATION IN THE DELINEATION OF TRUE VS PSEUDOMOSAICISM IN PRENATAL-DIAGNOSIS

Authors
SCHWARTZ S LEANACOX J
Citation
S. Schwartz et J. Leanacox, FLUORESCENT IN-SITU HYBRIDIZATION (FISH) - A NEW APPLICATION IN THE DELINEATION OF TRUE VS PSEUDOMOSAICISM IN PRENATAL-DIAGNOSIS, Prenatal diagnosis, 13(8), 1993, pp. 661-670
Citations number
14
Categorie Soggetti
Obsetric & Gynecology
Journal title
Prenatal diagnosis → ACNP
ISSN journal
01973851
Volume
13
Issue
8
Year of publication
1993
Pages
661 - 670
Database
ISI
SICI code
0197-3851(1993)13:8<661:FIH(-A>2.0.ZU;2-O
Abstract
Metaphase chromosomes and interphase nuclei from nine amniotic fluid c ultures were studied with fluorescence in situ hybridization (FISH). T he samples were initially analyzed with routine G-banding and were dia gnosed as having true mosaicism (five patients) or pseudomosaicism (fo ur patients). In our study, FISH analysis could provide additional inf ormation to distinguish pseudo- from true mosaicism by allowing interp hase studies and analysis of an increased number of metaphase spreads. These results suggest a multilinear origin of 'in situ' colonies of c ells.