Laparoscopic cholecystectomy (LC), which results in less postoperative
pain, disability, and scarring, has become an attractive alternative
method of surgical management of the ambulatory patient with gallbladd
er disease. The best procedure for severely ill patients who are poor
operative risks but require cholecystectomy, however, is unknown since
the operative morbidity and mortality of LC in this group of patients
has not been studied. All patients (177) undergoing cholecystectomy a
t one institution were evaluated. Based on their preoperative state of
health as defined by a modified acute physiologic score (APS), patien
ts were divided into two groups; one group was defined by an APS of le
ss than 10, indicating they were in good health, and the other had an
APS greater than or equal to 10, indicating that the group had multipl
e risk factors, predicting an increased postoperative morbidity and mo
rtality. Selection for either procedure, LC or open cholecystectomy (O
C), was made independently of the patient's preoperative status. Patie
nts' past medical histories; demographic, physiologic, and laboratory
data; and postoperative complications were evaluated. When all cholecy
stectomy patients were arranged into the respective risk groups, the a
ge and severity of illness scores (APS) between LC and OC were not sta
tistically different. Intraoperative and postoperative complications w
ere not significantly different when patients undergoing LC were compa
red to patients undergoing OC.-Laparoscopic cholecystectomy was associ
ated with decreased hospitalization when compared to patients undergoi
ng OC. The overall mortality of the patients undergoing OC was signifi
cantly greater than those undergoing LC. LC is an acceptable surgical
alternative for high-risk patients requiring cholecystectomy.