SYNTHESIS OF HALOGENATED BENZYLPYRROLES A ND BENZOYLPYRROLES

Several halogenated aroyl-1H-pyrroles of type 2, 14 and 19 are synthes ized by reaction of aroylchlorides with pyrrolyl-magnesium bromide, br omination or iodination of the pyrrole ring and demethylation with bor on tribromide. Furthermore, the synthesis of the naphthylpyrrole 19b w as performed by analogy with the synthesis of 1. Their antibiotic and cytotoxic activity is compared with 1, dn antibacterial, enzyme-inhibi tory and cytotoxic compound, isolated from the marine bacterium Altero monas luteoviolaceus.