SYNTHESIS AND BINDING OF NEW POLYFLUORINATED ARYL AZIDES TO ALPHA-CHYMOTRYPSIN - NEW REAGENTS FOR PHOTOAFFINITY-LABELING

Authors
SOUNDARARAJAN N LIU SH SOUNDARARAJAN S PLATZ MS
Citation
N. Soundararajan et al., SYNTHESIS AND BINDING OF NEW POLYFLUORINATED ARYL AZIDES TO ALPHA-CHYMOTRYPSIN - NEW REAGENTS FOR PHOTOAFFINITY-LABELING, Bioconjugate chemistry, 4(4), 1993, pp. 256-261
Citations number
39
Categorie Soggetti
Biology,Chemistry
Journal title
Bioconjugate chemistry → ACNP
ISSN journal
10431802
Volume
4
Issue
4
Year of publication
1993
Pages
256 - 261
Database
ISI
SICI code
1043-1802(1993)4:4<256:SABONP>2.0.ZU;2-2
Abstract
The preparation of several new, water-soluble, polyfluorinated aryl az ide reagents for use in photoaffinity labeling studies is described. T he ability of some of these reagents and their nonfluorinated controls to noncovalently bind to alpha-chrymotrypsin is reported. It is found that polyfluorination does not interfere with ligand binding.