ANALYSIS OF HERPES-VIRUS GROUP (DNA) FROM CEREBROSPINAL-FLUID IN VOGT-KOYANAGI-HARADA DISEASE

Introduction/Aim. In order to detect herpes virus group DNA including that of the Epstein-Barr virus (EBV) in patients with Vogt-Koyanagi-Ha rada disease (VKH), the authors employed the polymerase chain reaction (PCR) procedure using DNA from cerebrospinal fluid (CSF) obtained fro m patients with VKH. Method. Seven CSF samples were obtained from six definite, active VKH cases and DNA was isolated. DNA fragments contain ing parts of herpes simplex virus (HSV), herpes tester virus (VZV), cy tomegalo virus (CMV), EBV and human herpes virus type 6 (HHV-6) sequen ces were amplified by PCR. Results. No DNA fragment corresponding to t he DNA sequence of the herpes virus group was detected. Conclusion. Ou r results suggest that the herpes virus group does not have a close as sociation with the cause of VKH.