COMPARATIVE MAPPING OF 9 HUMAN CHROMOSOME-22Q LOCI IN THE LABORATORY MOUSE

We present a comparative map of genes on human chromosome 22q and homo logous loci in the mouse genome. Gene order in humans was established using a panel of somatic cell hybrids. Genetic maps spanning homologou s segments on three mouse chromosomes were generated using an interspe cific backcross. The conserved linkage between human chromosome 22 and mouse chromosome 16 includes two closely linked loci, Comt and Igl-1. The second conserved linkage involves human chromosome 22 and mouse c hromosome 11 and contains two genetically and physically linked loci, Lif and Nfh. Finally, conserved synteny involving mouse chromosome 15 and human chromosome 22 spans 30 cM and contains five loci (Acr, Bzrp, Dia-1, II2rb and Pdgfb). Loci within this conserved synteny have been sublocalized to different portions of human chromosome 22. The order of genes on mouse chromosome 15 and human chromosome 22 provides furth er evidence for chromosomal rearrangements within the conserved synten y that have occurred since the divergence of lineages leading to mice and humans.