SIMPLE AND EFFICIENT PALLADIUM-CATALYZED CARBONYLATION OF IODOXYARENES IN WATER UNDER MILD CONDITIONS

Authors
GRUSHIN VV ALPER H
Citation
Vv. Grushin et H. Alper, SIMPLE AND EFFICIENT PALLADIUM-CATALYZED CARBONYLATION OF IODOXYARENES IN WATER UNDER MILD CONDITIONS, Journal of organic chemistry, 58(18), 1993, pp. 4794-4795
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
18
Year of publication
1993
Pages
4794 - 4795
Database
ISI
SICI code
0022-3263(1993)58:18<4794:SAEPCO>2.0.ZU;2-I
Abstract
Iodoxyarenes (ArIO2) readily react with CO (1 atm) in water, in the pr esence of Na2[PdCl4] (0.1%) and Na2CO3 at 40-50-degrees-C, to give the corresponding carboxylic acids, ArCOOH, in 55-89% isolated yield. Par ticularly attractive features of the reaction are that, unlike most io doarenes, ArIO2 can be carbonylated in aqueous media without any organ ic solvents, due to their solubility in water and high reactivity.