POLYCYCLIC GUANIDINE-CONTAINING COMPOUNDS FROM THE MEDITERRANEAN SPONGE CRAMBE-CRAMBE - THE STRUCTURE OF 13,14,15-ISOCRAMBESCIDIN 800 AND THE ABSOLUTE STEREOCHEMISTRY OF THE PENTACYCLIC GUANIDINE MOIETIES OF THE CRAMBESCIDINS

Authors
JARESERIJMAN EA INGRUM AL CARNEY JR RINEHART KL SAKAI R
Citation
Ea. Jareserijman et al., POLYCYCLIC GUANIDINE-CONTAINING COMPOUNDS FROM THE MEDITERRANEAN SPONGE CRAMBE-CRAMBE - THE STRUCTURE OF 13,14,15-ISOCRAMBESCIDIN 800 AND THE ABSOLUTE STEREOCHEMISTRY OF THE PENTACYCLIC GUANIDINE MOIETIES OF THE CRAMBESCIDINS, Journal of organic chemistry, 58(18), 1993, pp. 4805-4808
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
18
Year of publication
1993
Pages
4805 - 4808
Database
ISI
SICI code
0022-3263(1993)58:18<4805:PGCFTM>2.0.ZU;2-C
Abstract
The absolute stereochemistry of the pentacyclic guanidine moieties of crambescidin 816 (1)1 and of 13,14,15-isocrambescidin 800 (4), a new m ember of this family, was determined, based on chiral GC analysis of a derivative of 2-hydroxybutanoic acid, an ozonolysis product of the cr ambescidins. Significantly less antiviral activity and cytotoxicity we re observed for 4.