CONTINUOUS 5-FLUOROURACIL INFUSION CAUSING ACUTE GASTRIC-MUCOSAL LESIONS

A 59-year-old woman with advanced gastric cancer was treated with cont inuous 5-fluorouracil infusion for thirty-five days. Endoscopy of the upper gastrointestinal tract was performed due to continuing nausea se ven days after the cessation of 5-fluorouracil infusion and revealed m ultiple erosions in the antrum which were absent before chemotherapy. Continuous 5-fluorouracil infusion was probably the cause of acute gas tric mucosal lesions and should be included in the differential diagno sis of dyspepsia in 5-FU-treated patients.