DELAYED SEIZURES FOLLOWING SEDATION WITH PROPOFOL

Seizures occurred in two adolescents approximately six hours after sed ation with propofol for bone marrow biopsy. Case #1 was a patient with chronic renal failure, hypertension, and anaemia. Case #2 had just be en diagnosed with acute lymphocytic leukaemia. Neither child had exper ienced seizures before, and both recovered without neurological sequel ae Although other factors may have caused the seizures, the episodes h ave raised concerns about the safety of propofol for patients travelli ng home after out-patient surgery Further study is required to explain the cause of this complication or, at least, to identify risk factors .