A. Holecyova et al., CONTRACTILITY OF THE RABBIT ABDOMINAL-AORTA 4 DAYS AFTER ENDOTHELIUM DENUDATION, Journal of vascular research, 30(4), 1993, pp. 224-230
Citations number
32
Categorie Soggetti
Hematology,"Medicine, General & Internal",Physiology
The purpose of this study was to evaluate contractility of the rabbit
abdominal aorta 4 days after de-endothelialization by balloon catheter
. The isometric tension of ring-segments in response to vasoactive age
nts was monitored. A significant enhancement of contraction to noradre
naline and serotonin was found in aortas 4 days after endothelium denu
dation as compared with controls with endothelium. The enhancement, ho
wever, did not differ from that found already in acutely denuded vesse
ls (immediate denudation). No significant difference in contractility
to potassium chloride was found in either group of denuded preparation
s as compared with controls. The sensitivity to all three vasoactive a
gents (EC50) was not influenced by denudation. These results indicate
that changes in the contractility of denuded vessels are predominantly
a consequence of lacking the endothelium as a producer of endothelium
-derived relaxing factor. The access of mitogens to the media does not
seem to interfere with the magnitude of contraction 4 days after denu
dation.