SMITH-FINEMAN-MYERS SYNDROME - REPORT ON A LARGE FAMILY

Smith-Fineman-Myers syndrome is considered an X-linked mental retardat ion (XLMR) syndrome. Three families have been reported to date. Howeve r, none presented a typical pattern of X-linked inheritance. Here we r eported on 5 males with Smith- Fineman-Myers syndrome with similar phe notypic expression as in those cases reported previously; they were di stributed in 4 sibships of one large maternal kindred. This finding ad ds strong support to the hypothesis of the Smith-Fineman-Myers syndrom e being a rare XLMR syndrome. (C) 1993 Wiley-Liss, Inc.