GLUTATHIONE-S-TRANSFERASE YC CDNA FROM SYRIAN-HAMSTER KIDNEY

cDNA encoding alpha-class glutathione S-transferase Yc (GSTYc) has bee n isolated from a Syrian hamster kidney library, and its nucleotide se quence (968 bp) has been determined. Analysis of the deduced amino aci d sequence revealed a high level of identity between Syrian hamster GS TYc, rat GST Yc1 and Yc2 and mouse GSTYc. Northern-blot experiments de monstrated that Syrian hamster GSTYc expression is tissue-specific. A GSTYc mRNA of approx. 1 kb is expressed in liver, kidney, vas deferens and epididymis. Expression of the GSTYc transcript was not detected i n testis or uterus.