The objective of this study is to explore the nature and extent of the
cognitive behavioral response to treatment, and the accompanying anxi
ety and/or depression in cancer patients with advanced disease. In a m
ulticenter study, 247 patients treated with palliative radiotherapy fi
lled out a questionnaire before start of treatment. The questionnaire
consisted of Impact of Event Scale (IES), General Health Questionnaire
(GHQ-20), and two questions assessing pain intensity. Seventy percent
of the patients reported a high level of psychological distress. The
mean score of the patient population on the IES was 14.4 (IES intrusio
n) and 15.3 (IES avoidance). The mean Likert score on the GHQ-20 was 2
7.3. Patients with poor performance status and pain were most distress
ed. In order to improve patients' care and support, cases at risk must
be identified. In the present population, psychological distress is r
elated to pain and reduced performance status.