SPHEROID CONTROL OF MALIGNANT GLIOMA CELL-LINES AFTER FRACTIONATED-IRRADIATION - RELATION TO THE SURVIVING FRACTIONS AT 2-GY AND COLONY-FORMING EFFICIENCIES IN A SOFT AGAR CLONOGENIC-ASSAY

Authors
STUSCHKE M BUDACH V KALFF RL SACK H BAMBERG M REINHARDT V FELDMANN HJ
Citation
M. Stuschke et al., SPHEROID CONTROL OF MALIGNANT GLIOMA CELL-LINES AFTER FRACTIONATED-IRRADIATION - RELATION TO THE SURVIVING FRACTIONS AT 2-GY AND COLONY-FORMING EFFICIENCIES IN A SOFT AGAR CLONOGENIC-ASSAY, Radiotherapy and oncology, 27(3), 1993, pp. 245-251
Citations number
22
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Journal title
Radiotherapy and oncology → ACNP
ISSN journal
01678140
Volume
27
Issue
3
Year of publication
1993
Pages
245 - 251
Database
ISI
SICI code
0167-8140(1993)27:3<245:SCOMGC>2.0.ZU;2-7
Abstract
Spheroid control doses (SCD50) were determined for ten human glioma li nes after fractionated irradiation under oxic conditions. In addition, SF2 values and colony forming efficiencies (CFE) were measured in a s oft agarose clonogenic assay. A significant relationship existed betwe en the SCD50 values and the SF2-CFE data pairs (p = 0.01) but the SCD5 0 values were higher than expected from the SF2 and CFE values. This c omparison shows the influence of environmental factors (different in b oth model systems) on reproductive tumour cell death after irradiation .