Cy. Tong et al., TECHNIQUES FOR THE MEASUREMENT OF THE LOCAL MYOCARDIAL EXTRACTION EFFICIENCY FOR INERT DIFFUSIBLE CONTRAST AGENTS SUCH AS GADOPENTATE DIMEGLUMINE, Magnetic resonance in medicine, 30(3), 1993, pp. 332-336
We have previously shown that the concentration of Gd-DTPA as a functi
on of time ([Gd-DTPA]t(t)) in the myocardium following an intravenous
bolus injection of Gd-DTPA can be modeled using the Modified Kety Equa
tion. Fitting this model to measurements of [Gd-DTPA]t(t) in a region
of myocardium would allow the determination of myocardial distribution
volume (lambda) and the product of flow (F) and extraction efficiency
(E), i.e., FE. Thus, to measure F, E must be known. We describe here
techniques developed to measure local values of E in normal and diseas
ed myocardium. These techniques are valid for any inert diffusible MR
contrast agent.