AN INFORMATION THEORY-BASED EVALUATION OF STATIONARY PHASES DEVELOPEDFOR OPTICAL RESOLUTION OF AMINO-ACIDS

Naphthylethylurea multiple-bonded chiral stationary phases prepared fo r the optical resolution of p-bromophenylcarbamyl derivatives of enant iomeric amino acids are examined from the viewpoint of information the ory. The criterion used is the function of mutual information (FUMI) w hich describes the precision of analysis as a function of peak shape ( area and width), overlap and noise level. The length of the polyethyle neamine spacer in the chiral stationary phases is evaluated by the pre cision (FUMI) calculated from the peak shape and overlap. The best col umn is defined as the one which gives the highest precision. The tempe rature effect on the precision is also examined.