ONLINE SOLUTION STABILITY DETERMINATION OF PHARMACEUTICALS BY CAPILLARY ELECTROPHORESIS

Good agreement between the impurity levels in a batch of a related imp urity of ranitidine were obtained by CE and HPLC. A solution of the im purity was positioned on the CE autosampler and analysed sequentially. The extent of degradation was monitored by loss of main peak and the formation of two principal degradation products. It was found that aft er 9.25 hours only 2 % area/area of the original impurity remained. Bu ffering of the sample solution to pH 7 was shown to minimise this degr adation. Unattended in-situ stability testing of an solution of the im purity in water was performed by CE.