FURTHER-STUDIES ON THE ADJUVANTICITY OF STEARYL TYROSINE AND ESTER ANALOGS

A new family of immunoadjuvants, long-chain stearyl esters of amino ac ids and peptides, are described and examined with bacterial and viral vaccines. The parent compound, stearyl tyrosine, displayed significant adjuvant activity with these vaccines. Stearyl glycyl glycine display ed superior activity with viral vaccines. A number of analogues of ste aryl tyrosine were adjuvant-active. Further, these adjuvants were able to elicit a neutralizing antibody response. Stearyl tyrosine and stea ryl ester analogues represent promising adjuvants for human vaccines.