REGIOSELECTIVE ENZYME-CATALYZED SYNTHESIS OF PYRAZOLE-CONTAINING PODANDS

Initial results are described about a new synthesis of a family of the acyclic cation-complexing compounds named podands containing a pyrazo le moiety as a part of the molecule. This synthesis was carried out by lipase-catalyzed transesterification of the corresponding pyrazole-3, 5-dicarbethoxy derivative with di- and triethyleneglycol monomethyleth er; it afforded good yields and a high degree of regioselectivity in N -substituted pyrazoles where 3 and 5 positions are not equivalents. As an initial approach, a simpler model of transesterification with n-oc tanol was studied.