Ag. Aguirre et al., SIMULATION OF A MULTICOLUMN RECIRCULATED PACKED-BED REACTOR (MRPBR) FOR PENICILLIN ACYLASE, Bioprocess engineering, 9(4), 1993, pp. 147-154
Enzyme reactors for the industrial hydrolysis of penicillin are analyz
ed in terms of biocatalyst stability to pH. A multicolumn system with
packed beds placed in parallel and operating under recirculating condi
tions is proposed as an adequate reactor for this process. The system
is studied both experimentally and with the aid of a simulation progra
m.