COADMINISTRATION OF (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACIDAND ARACHIDONIC-ACID POTENTIATES SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPAL SLICES

Authors
COLLINS DR DAVIES SN
Citation
Dr. Collins et Sn. Davies, COADMINISTRATION OF (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACIDAND ARACHIDONIC-ACID POTENTIATES SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPAL SLICES, European journal of pharmacology, 240(2-3), 1993, pp. 325-326
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
240
Issue
2-3
Year of publication
1993
Pages
325 - 326
Database
ISI
SICI code
0014-2999(1993)240:2-3<325:CO(A>2.0.ZU;2-W
Abstract
Perfusion of the 1S,3R isomer of trans-aminocyclopentane-1,3-dicarboxy lic acid (t-ACPD, 50 muM), or arachidonic acid (10 muM), for 5 min pro duced only depression of the field excitatory postsynaptic potential r ecorded in the CA1 region of rat hippocampal slices from which the CA3 region had been removed. However, perfusion of t-ACPD and arachidonic acid in combination induced a rapid potentiation of the response whic h in 4/6 slices was maintained for at least 90 min.