Jg. Weers, A PHYSICOCHEMICAL EVALUATION OF PERFLUOROCHEMICALS FOR OXYGEN-TRANSPORT APPLICATIONS, Journal of fluorine chemistry, 64(1-2), 1993, pp. 73-93
The history of perfluorochemicals as oxygen transport agents and a com
parison of potential second generation perfluorochemicals is outlined.
1-Bromoperfluorooctane (perflubron, perfluorooctyl bromide, PFOB), a
linear aliphatic perfluorochemical, has unexpected lipophilic properti
es relative to other perfluorochemicals. The enhanced lipophilicity le
ads to the unique combination of excellent emulsion stability and an e
xceptionally short organ retention time. Other medically desirable pro
perties of PFOB include: high purity and definition; excellent gas sol
ubility; superior compatibility with egg yolk phospholipids; the abili
ty to provide contrast; low vapor pressure; low kinematic viscosity; a
nd a positive spreading coefficient on a saline solution.