SYNTHESIS OF 25]IODOETHENYL]ANDROSTA-4,6-DIEN-17-BETA-OL-3-ONE, AN ACTIVE-SITE-DIRECTED PHOTOAFFINITY RADIOLABEL FOR ANDROGEN-BINDING PROTEINS

Authors
CRUZ PJD SMITH HE DANZO BJ CLANTON JA MASON NS
Citation
Pjd. Cruz et al., SYNTHESIS OF 25]IODOETHENYL]ANDROSTA-4,6-DIEN-17-BETA-OL-3-ONE, AN ACTIVE-SITE-DIRECTED PHOTOAFFINITY RADIOLABEL FOR ANDROGEN-BINDING PROTEINS, Journal of labelled compounds & radiopharmaceuticals, 33(9), 1993, pp. 853-862
Citations number
35
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
33
Issue
9
Year of publication
1993
Pages
853 - 862
Database
ISI
SICI code
0362-4803(1993)33:9<853:SO2AA>2.0.ZU;2-O
Abstract
The active-site-directed photoaffinity radiolabel for androgen-binding proteins, 125]iodoethenyl]androsta-4,6-dien-17beta-ol-3-one, was prep ared by reaction of yltin(IV)ethenyl]androsta-4,6-dien-17beta-ol-3-one with carrier added sodium iodide-125 in the presence of hydrogen pero xide and acetic acid. Purification by HPLC gave the radiolabeled stero id in 52% radiochemical yield with a specific activity of 27 Ci/mmol a nd 100% radiochemical purity.