STEREOCONTROLLED CATALYTIC ASYMMETRIC REDUCTION OF KETONES WITH OXAZABOROLIDINES DERIVED FROM NEW CHIRAL AMINO-ALCOHOLS

Authors
KIM YH PARK DH BYUN IS YOON IK PARK CS
Citation
Yh. Kim et al., STEREOCONTROLLED CATALYTIC ASYMMETRIC REDUCTION OF KETONES WITH OXAZABOROLIDINES DERIVED FROM NEW CHIRAL AMINO-ALCOHOLS, Journal of organic chemistry, 58(17), 1993, pp. 4511-4512
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
17
Year of publication
1993
Pages
4511 - 4512
Database
ISI
SICI code
0022-3263(1993)58:17<4511:SCAROK>2.0.ZU;2-5
Abstract
The highly stereocontrolled enantioselective reduction of ketones in t he presence of catalytic amounts of new chiral (S)-beta-amino alcohols 1 and 2 with borane in THF at -78-degrees-C proceeds in high chemical and optical yields; secondary alcohols with the R-configuration are o btained in the presence of 1b, but secondary alcohols with the S-confi guration are obtained in the presence of 2a.