SYNTHESIS OF VARACIN, A CYTOTOXIC NATURALLY-OCCURRING BENZOPENTATHIEPIN ISOLATED FROM A MARINE ASCIDIAN

Authors
FORD PW DAVIDSON BS
Citation
Pw. Ford et Bs. Davidson, SYNTHESIS OF VARACIN, A CYTOTOXIC NATURALLY-OCCURRING BENZOPENTATHIEPIN ISOLATED FROM A MARINE ASCIDIAN, Journal of organic chemistry, 58(17), 1993, pp. 4522-4523
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
17
Year of publication
1993
Pages
4522 - 4523
Database
ISI
SICI code
0022-3263(1993)58:17<4522:SOVACN>2.0.ZU;2-Z
Abstract
The total synthesis of varacin (1), a cytotoxic metabolite isolated fr om a marine ascidian, has been accomplished in 11 steps from vanillin, providing unambiguous confirmation of the unique dopamine-related ben zopentathiepin structure.