BIOSYNTHESIS OF SPICIFERONE-A AND SPICIFERNIN, BIOACTIVE METABOLITES OF THE PHYTOPATHOGENIC FUNGUS, COCHLIOBOLUS-SPICIFER

Authors
NAKAJIMA H FUJIMOTO H MATSUMOTO R HAMASAKI T
Citation
H. Nakajima et al., BIOSYNTHESIS OF SPICIFERONE-A AND SPICIFERNIN, BIOACTIVE METABOLITES OF THE PHYTOPATHOGENIC FUNGUS, COCHLIOBOLUS-SPICIFER, Journal of organic chemistry, 58(17), 1993, pp. 4526-4528
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
58
Issue
17
Year of publication
1993
Pages
4526 - 4528
Database
ISI
SICI code
0022-3263(1993)58:17<4526:BOSASB>2.0.ZU;2-Y
Abstract
The biosynthetic pathways to spiciferone A and spicifernin were invest igated by means of incorporation experiments with [1-C-13], [2-C-13], [1,2-C-13], and [1-C-13,H-2(3)] acetate and [S-(CH3)-C-13]-L-methionin e. The incorporation patterns suggested that they are produced from a common precursor, which is derived from a hexaketide and two C1 units, after undergoing modifications including the unique C-C bond cleavage by retroaldol condensation.