Ra. Bartsch et al., A NOVEL 12-MEMBERED TRIAZAOXAMACROCYCLE-N,N',N''-TRIACETIC ACID INDICATOR FOR COLORIMETRIC DETERMINATION OF CALCIUM, Journal of organic chemistry, 58(17), 1993, pp. 4681-4684
The synthesis of a novel chromogenic triazaoxamacrocycle bearing three
acetic acid groups and a 2,4,6-trinitroanilino chromophore, for gener
ation of a spectrophotometric response, is described. As determined by
potentiometric titration conducted in water, tetraionizable chromoion
ophore 4 forms a rather weak 1:1 complex with calcium (K(s) = 9.5 X 10
(2) M-1) but exhibits very high selectivity for Ca2+ over Mg2+ at neut
ral pH. Cation responses at pH 7.0, 8.0, 9.0, and 10.0 are determined.
The response of 4 to calcium is linear from 2 x 10(-5) to 1 x 10(-4)
M Ca2+.