Jp. Braun et al., CLINICAL ENZYMOLOGY FOR THE ASSESSMENT OF ORGAN DAMAGE - INTERSPECIFIC DIFFERENCES, Comparative haematology international, 3(1), 1993, pp. 27-32
Enzyme activities in serum/plasma or urine are the most widely used ma
rkers of organ damage as well in human or animal clinics as in experim
ental toxicology. Significant interspecific differences can be observe
d for enzyme distribution in various species, extracellular metabolism
, preanalytical and analytical conditions. Thus, to avoid any misinter
pretation, all these criteria have to be documented and/or validated b
efore use.