A COMPARATIVE-STUDY OF ENZYMURIA, IN THE RAT, OF THE DRUG-COMBINATIONS AMIKACIN VANCOMYCIN AND AMIKACIN TEICOPLANIN

The aim of this study was to compare nephrotoxicity of the combination s amikacin/vancomycin and amikacin/teicoplanin. Eighteen male Wistar r ats were divided into 3 groups of 6 animals each. The first group rece ived 50 mg.kg-1 of amikacin (i.m. route) and 100 mg.kg-1 of vancomycin (i.p. route). The second group received 50 mg.kg-1 of amikacin (i.m. route) and 40 mg.kg-1 of teicoplanin (i.p. route). The third group rec eived an isotonic solution of sodium chloride. The antibiotics were in jected for a period of 6 days. Urine samples of animals were taken 24 h before the beginning of the experiment, then every day, throughout t he duration of the treatment (6 days), continuing for an additional 3 days following completion of the administration of the drugs. There we re no significant modifications in the urinary excretions of alanine a minopeptidase and the creatinine between the 3 groups, but in the grou p receiving amikacin/teicoplanin, we observed between days 3 and 8 an increase in the excretion of N-acetyl-beta-D-glucosaminidase when comp ared to the group receiving amikacin/vancomycin (p less-than-or-equal- to 0.05) and to the control group (p less-than-or-equal-to 0.01).