2-DIMENSIONAL INVERSE LAPLACE TRANSFORM NMR - ALTERED RELAXATION-TIMES ALLOW DETECTION OF EXCHANGE-CORRELATION

A pulse sequence for a two-dimensional inverse Laplace transform NMR e xperiment is proposed and demonstrated. The experiment is analogous to the two-dimensional Fourier transform protocol called EXSY, but detec ts exchange by monitoring alterations in the transverse relaxation tim e rather than the NMR frequency. The sequence may be useful for measur ement of exchange and diffusion of water in vivo and for detecting slo w exchange phenomena in glassy polymers.