Er. Arndt et Es. Stevens, VACUUM-ULTRAVIOLET CIRCULAR-DICHROISM STUDIES OF SIMPLE SACCHARIDES, Journal of the American Chemical Society, 115(17), 1993, pp. 7849-7853
The circular dichroism (CD) of simple sugars was extended to 140 nm us
ing film samples. The 150-190-nm region can be decomposed into four co
mponents. The signs of these four components are strictly correlated w
ith anomeric configuration. Dominant contributions to CD arise from el
ectronic transitions localized on the oxygen atoms of the ether chromo
phores. The CD below 150 nm represents the onset of the lowest energy
sigma-sigma transition, the sign of which is also correlated with ano
meric configuration. By extrapolation, its center is estimated to be a
t approximately 120-130 nm. The CD spectra of representative disacchar
ides contain a conformation-dependent contribution,indicating the usef
ulness of CD as a conformational probe. The results reported here prov
ide a basis for developing improved interpretive models.