SYNTHESIS AND EVALUATION OF THE ANTIVIRAL ACTIVITY OF ACYCLIC NUCLEOSIDES CARRYING FLUORINE AND SULFUR SUBSTITUENTS

Authors
BRAVO P RESNATI G VIANI F DEMONTIS A CORRIAS S LACOLLA P
Citation
P. Bravo et al., SYNTHESIS AND EVALUATION OF THE ANTIVIRAL ACTIVITY OF ACYCLIC NUCLEOSIDES CARRYING FLUORINE AND SULFUR SUBSTITUENTS, Il Farmaco, 48(8), 1993, pp. 1113-1120
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
8
Year of publication
1993
Pages
1113 - 1120
Database
ISI
SICI code
0014-827X(1993)48:8<1113:SAEOTA>2.0.ZU;2-#
Abstract
-2',3'-Seco nucleosides 5 carrying fluorine and sulfur substituents at C-3' and C-5, respectively, of acyclic sugar moiety were synthesized in enantiomerically and diastereoisomerically pure form. These product s and some structurally similar 1',2'-seco-2'-nor-and 1',2'-seco-nucle osides 3 and 4 were tested in vitro for cytotoxicity and antiviral act ivity. At non-cytotoxic concentrations the compounds were inactive aga inst human immunodeficiency virus and herpes simplex virus type-1.