During a space mission flown in microgravity early changes in intraocu
lar pressure due to the fluid shift effect in microgravity were analyz
ed with an automatic self-tonometer. In total, 13 pressure readings pe
r eye were obtained during the mission. The first pressure readings 16
min after reaching microgravity revealed a 92% rise in intraocular pr
essure compared to the daytime-correlated baseline data on earth follo
wed by an adaptation phase lasting for several hours. Diurnal pressure
profiles during the mission showed no relevant difference in altitude
and amplitude.