CONCENTRATION OF ASCORBIC-ACID IN BLOOD-P LASMA OF LAMBS AND DOGS BEFORE AND AFTER ORAL APPLICATION OF ASCORBIC-ACID AND ASCORBYLPHOSPHATE - COMPOUNDS AND EXCRETION IN THE URINE OF DOGS 8 HOURS AFTER

After the oral application of ascorbic acid (50 mg/kg body weight) the highest increase in the concentration in the blood plasma of 1 week a nd 2 weeks old lambs was determined after 5 hours. In the 4 week old l ambs the increase was lower. There was still an elevated concentration in the blood plasma after 8 hours. After the installation of ascorbic acid in a buffer-solution into the rumen there was no resorption. Aft er the application of a mixture of ascorbyltriphosphate (main portion) , of ascorbyldiphosphate and of ascorbylmonophosphate in an equivalent dose of ascorbic acid to lambs of the same age in the course of 5 hou rs the same increase in the concentration of ascorbic acid in the plas ma was analysed. At dogs of the race ''beagle'' after the intake of as corbic acid (50 mg/kg b.w.) respectively of an equivalent dose of asco rbylphosphate-compounds the highest concentration in the blood plasma existed after 2 hours; there was still a significant increase after 8 hours. In the course of 8 hours in the dogs between 7,1 and 11,2 % of the ingested amount of ascorbic acid were excreted in the urine.