SYNTHESIS OF OXA ANALOGS OF PORPHOBILINOGEN (PBG) AS PROBES FOR MECHANISTIC STUDIES OF PBG DEAMINASE

Authors
DANSODANQUAH RE SCOTT AI BECKER D
Citation
Re. Dansodanquah et al., SYNTHESIS OF OXA ANALOGS OF PORPHOBILINOGEN (PBG) AS PROBES FOR MECHANISTIC STUDIES OF PBG DEAMINASE, Tetrahedron, 49(36), 1993, pp. 8195-8210
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
36
Year of publication
1993
Pages
8195 - 8210
Database
ISI
SICI code
0040-4020(1993)49:36<8195:SOOAOP>2.0.ZU;2-D
Abstract
Three oxa analogs of porphobilinogen (PBG) 2, 27, and 29 were synthesi zed from 3-hydroxymethylfuran. The target molecules were prepared by i ntroducing first the beta-acetate sidechain, then constructing propion ate side chains on the furan nucleus into which the aminomethyl group was introduced at position 2 via the corresponding aldehyde.