ASSESSMENTS OF EMBRYO-TRANSFER AFTER IN-VITRO FERTILIZATION - EFFECTSOF GLYCERYL TRINITRATE

The role of embryo transfer and its associated difficulties on the out come of human in-vitro fertilization (IVF) were examined using a stand ardized procedure and a scoring system (embryo transfer scores 1 - 5). This system was used to assess any effects of the smooth muscle relax ant glyceryl trinitrate (GTN) on embryo transfer. Patients (n = 120) w ere randomized in a double-blind manner at their first embryo transfer to receive sublingual GTN or placebo before the transfer. Retrospecti ve analysis showed that higher pregnancy rates were associated with un complicated transfers (score 1; P < 0.01). The outcome measures includ ed pregnancy rate, total time of cervical manipulation (embryo transfe r time) and embryo transfer score. All pregnancies had a transfer scor e of 1 or 2, but no recorded parameter differentiated between pregnant or non-pregnant cycles, and GTN had no significant effect on any para meter.