Ja. Rininger et al., MURINE HEPATIC P53, RB, AND CDK INHIBITORY PROTEIN EXPRESSION FOLLOWING ACUTE 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) EXPOSURE, Chemosphere, 34(5-7), 1997, pp. 1557-1568
This study examined the expression of murine hepatic tumor suppressor
and cell cycle inhibitory proteins in response to acute 2,3,7,8-tetrac
hlorodibenzo-p-dioxin (TCDD) dosing in Balb/c mice. Elevations in expr
ession of p53, retinoblastoma (Rb) protein, p16(Ink4), p21(Wafl) and p
27(Kip1) were observed six days after a single dose of 0.25, 0.5, 1 or
2 mu g TCDD/kg. These data suggest that the TCDD-induced inhibition o
f hepatocyte proliferation in vivo could be attributed to the expressi
on of cell cycle inhibitory proteins. (C) 1997 Elsevier Science Ltd.