MURINE HEPATIC P53, RB, AND CDK INHIBITORY PROTEIN EXPRESSION FOLLOWING ACUTE 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) EXPOSURE

Authors
RININGER JA STOFFREGEN DA BABISH JG
Citation
Ja. Rininger et al., MURINE HEPATIC P53, RB, AND CDK INHIBITORY PROTEIN EXPRESSION FOLLOWING ACUTE 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) EXPOSURE, Chemosphere, 34(5-7), 1997, pp. 1557-1568
Citations number
45
Categorie Soggetti
Environmental Sciences
Journal title
Chemosphere → ACNP
ISSN journal
00456535
Volume
34
Issue
5-7
Year of publication
1997
Pages
1557 - 1568
Database
ISI
SICI code
0045-6535(1997)34:5-7<1557:MHPRAC>2.0.ZU;2-Q
Abstract
This study examined the expression of murine hepatic tumor suppressor and cell cycle inhibitory proteins in response to acute 2,3,7,8-tetrac hlorodibenzo-p-dioxin (TCDD) dosing in Balb/c mice. Elevations in expr ession of p53, retinoblastoma (Rb) protein, p16(Ink4), p21(Wafl) and p 27(Kip1) were observed six days after a single dose of 0.25, 0.5, 1 or 2 mu g TCDD/kg. These data suggest that the TCDD-induced inhibition o f hepatocyte proliferation in vivo could be attributed to the expressi on of cell cycle inhibitory proteins. (C) 1997 Elsevier Science Ltd.