GAS-CHROMATOGRAPHIC SEPARATION AND DETERMINATION OF ETHYL CHLOROACETATE REACTION MIXTURES

Ethyl chloroacetate (EGA) is a valuable chemical used in the preparati on of crop protection agents and pharmaceutical intermediates. It is g enerally prepared by the reaction of monochloroacetic acid(MCA) and et hanol. Selective, accurate and rapid analytical methods are essential for monitoring the reaction pathway and quantitative estimation of the products during the process development of EGA. A gas chromatographic (GC) method has been developed for the separation and quantitative de termination of carbontetrachloride, ethanol, water and ECA using penty l acetate as an internal standard. The method has been successfully ap plied for the determination of the components of reaction mixtures of EGA.