BLEOMYCIN INCREASES AMIKACIN AND STREPTOMYCIN RESISTANCE IN ESCHERICHIA-COLI HARBORING TRANSPOSON TN5

Authors
BLAZQUEZ J MARTINEZ JL BAQUERO F
Citation
J. Blazquez et al., BLEOMYCIN INCREASES AMIKACIN AND STREPTOMYCIN RESISTANCE IN ESCHERICHIA-COLI HARBORING TRANSPOSON TN5, Antimicrobial agents and chemotherapy, 37(9), 1993, pp. 1982-1985
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
9
Year of publication
1993
Pages
1982 - 1985
Database
ISI
SICI code
0066-4804(1993)37:9<1982:BIAASR>2.0.ZU;2-O
Abstract
The antitumor antibiotic bleomycin acts as a transcriptional inducer o f the neo-ble-str operon of the transposon Tn5, increasing the resista nce level to streptomycin and amikacin in Tn5-containing Escherichia c oli. The mechanism may involve a recA-independent induction mediated b y DNA damage.