DETECTION AND CHARACTERIZATION OF MUPIROCIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS

Authors
JANSSEN DA ZARINS LT SCHABERG DR BRADLEY SF TERPENNING MS KAUFFMAN CA
Citation
Da. Janssen et al., DETECTION AND CHARACTERIZATION OF MUPIROCIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS, Antimicrobial agents and chemotherapy, 37(9), 1993, pp. 2003-2006
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
9
Year of publication
1993
Pages
2003 - 2006
Database
ISI
SICI code
0066-4804(1993)37:9<2003:DACOMR>2.0.ZU;2-0
Abstract
Fourteen mupirocin-resistant Staphylococcus aureus strains were isolat ed over 18 months; 12 exhibited low-level resistance, while two showed high-level resistance. Highly mupirocin-resistant strains contained a large plasmid which transferred mupirocin resistance to other S. aure us strains and to Staphylococcus epidermidis. This plasmid and pAM899- 1, a self-transferable gentamicin resistance plasmid, have molecular a nd biologic similarities.