NOVEL, PLASMID-ENCODED, TEM-DERIVED EXTENDED-SPECTRUM BETA-LACTAMASE IN KLEBSIELLA-PNEUMONIAE CONFERRING HIGHER RESISTANCE TO AZTREONAM THAN TO EXTENDED-SPECTRUM CEPHALOSPORINS

Authors
ARLET G ROUVEAU M FOURNIER G LAGRANGE PH PHILIPPON A
Citation
G. Arlet et al., NOVEL, PLASMID-ENCODED, TEM-DERIVED EXTENDED-SPECTRUM BETA-LACTAMASE IN KLEBSIELLA-PNEUMONIAE CONFERRING HIGHER RESISTANCE TO AZTREONAM THAN TO EXTENDED-SPECTRUM CEPHALOSPORINS, Antimicrobial agents and chemotherapy, 37(9), 1993, pp. 2020-2023
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
9
Year of publication
1993
Pages
2020 - 2023
Database
ISI
SICI code
0066-4804(1993)37:9<2020:NPTEBI>2.0.ZU;2-U
Abstract
A clinical isolate of Klebsiella pneumoniae was more resistant to aztr eonam than to cefotaxime and ceftazidime. It produced a clavulanate-su sceptible beta-lactamase with an isoelectric point of 6.3 which readil y hydrolyzed penicillins, cefotaxime, and ceftazidime, but which hydro lyzed aztreonam poorly. The enzyme was encoded by a gene on a 15-kb pl asmid; the gene hybridized with an intragenic DNA probe of bla(TEM).