INFLUENCE OF CIRCADIAN-STAGE-DEPENDENT DOSING SCHEDULE ON NEPHROTOXICITY AND PHARMACOKINETICS OF ISEPAMICIN IN RATS

Authors
YOSHIYAMA Y NISHIKAWA S SUGIYAMA T KOBAYASHI T SHIMADA H TOMONAGA F OHDO S OGAWA N NAKANO S
Citation
Y. Yoshiyama et al., INFLUENCE OF CIRCADIAN-STAGE-DEPENDENT DOSING SCHEDULE ON NEPHROTOXICITY AND PHARMACOKINETICS OF ISEPAMICIN IN RATS, Antimicrobial agents and chemotherapy, 37(9), 1993, pp. 2042-2043
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
9
Year of publication
1993
Pages
2042 - 2043
Database
ISI
SICI code
0066-4804(1993)37:9<2042:IOCDSO>2.0.ZU;2-F
Abstract
Nephrotoxicity was more marked in rats receiving isepamicin at midligh t than at middark. And, the once-daily administration at middark induc ed a lesser degree of nephrotoxicity than the twice-daily injection, w hich indicates that the once-daily treatment therapy may have potentia l value in the clinical use of aminoglycosides.